Open AccessIn-Silico and In-Vitro Analysis of Human SOS1 Protein Causing Noonan Syndrome - A Novel Approach to Explore the Molecular Pathways
Author(s) -
Vinoth Sigamani,
Sheeja Rajasingh,
Narasimman Gurusamy,
Arunima Panda,
Johnson Rajasingh
Publication year - 2021
Publication title -
current genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 64
eISSN - 1875-5488
pISSN - 1389-2029
DOI - 10.2174/1389202922666211130144221
Subject(s) - in silico , noonan syndrome , hras , nonsynonymous substitution , dbsnp , genetics , biology , gene , mutation , costello syndrome , ptpn11 , mutant , single nucleotide polymorphism , microbiology and biotechnology , kras , genotype , genome
Perform in-silico analysis of human SOS1 mutations to elucidate their pathogenic role in Noonan syndrome (NS).