Open AccessProteasome Activator Blm10 Regulates Transcription Especially During Aging
Author(s) -
YuShan Chen,
Xia Han,
Kui Lin,
Tiancai Jiang,
XiaoBo Qiu
Publication year - 2021
Publication title -
current genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 64
eISSN - 1875-5488
pISSN - 1389-2029
DOI - 10.2174/1389202922666210601094643
Subject(s) - histone , transcription (linguistics) , biology , proteasome , microbiology and biotechnology , chromatin , transcription coregulator , histone modifying enzymes , transcription factor , e box , acetylation , general transcription factor , gene expression , promoter , nucleosome , gene , biochemistry , chromatin remodeling , philosophy , linguistics
Histones are basic elements of the chromatin and are critical to controlling chromatin structure and transcription. The proteasome activator PA200 promotes the acetylation-dependent proteasomal degradation of the core histones during spermatogenesis, DNA repair, transcription, and cellular aging and maintains the stability of histone marks.