Open AccessA Brief Review of circRNA Biogenesis, Detection, and Function
Author(s) -
Ying Liang,
Niannian Liu,
Le Yang,
Jianjun Tang,
Yinglong Wang,
Ming Meng
Publication year - 2021
Publication title -
current genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 64
eISSN - 1875-5488
pISSN - 1389-2029
DOI - 10.2174/1389202922666210331130722
Subject(s) - circular rna , computational biology , biogenesis , rna splicing , rna , intron , biology , exon , gene silencing , microrna , gene , genetics
Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments.