Open AccessHypothetical Proteins as Predecessors of Long Non-coding RNAs
Author(s) -
Girik Malik,
Tanu Agarwal,
Utkarsh Raj,
Vijayaraghava Seshadri Sundararajan,
Obul Reddy Bandapalli,
Prashanth Suravajhala
Publication year - 2020
Publication title -
current genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 64
eISSN - 1875-5488
pISSN - 1389-2029
DOI - 10.2174/1389202921999200611155418
Subject(s) - gene , open reading frame , genome , computational biology , intergenic region , biology , annotation , context (archaeology) , genetics , untranslated region , rna , peptide sequence , paleontology
Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism, but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5' UTR or intergenic regions of the genes whose lengths are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in the context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.