Open AccessA Bias in the Reading of the Genetic Code of Escherichia coli is a Characteristic for Genes that Specify Stress-induced MazF-mediated Proteins
Author(s) -
Akanksha Nigam,
Adi Oron-Gottesman,
Hanna EngelbergKulka
Publication year - 2020
Publication title -
current genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 64
eISSN - 1875-5488
pISSN - 1389-2029
DOI - 10.2174/1389202921999200606215305
Subject(s) - endoribonuclease , escherichia coli , ribosome , open reading frame , translation (biology) , gene , genetic code , start codon , biology , rna , transfer rna , antitoxin , messenger rna , genetics , toxin , rnase p , peptide sequence
Escherichia coli (E. coli) mazEF, a stress-induced toxin-antitoxin (TA) system, has been studied extensively. The MazF toxin is an endoribonuclease that cleaves RNAs at ACA sites. Thereby, under stress, the induced MazF generates a Stress-induced Translation Machinery (STM), composed of MazF processed mRNAs and selective ribosomes that specifically translate the processed mRNAs.