Open AccessAssessment of Expression of Homeobox A5 in Endometrial Cancer on the mRNA and Protein Level
Author(s) -
Konrad Dziobek,
Marcin Opławski,
Nikola Zmarzły,
Beniamin O Gabarek,
Robert Kiełbasiński,
Kamil Kiełbasiński,
Przemysław Kieszkowski,
Karol Talkowski,
Dariusz Boroń
Publication year - 2020
Publication title -
current pharmaceutical biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.555
H-Index - 85
eISSN - 1873-4316
pISSN - 1389-2010
DOI - 10.2174/1389201021666191227121627
Subject(s) - endometrial cancer , cancer , homeobox , immunohistochemistry , transcriptome , biology , pathological , messenger rna , cancer research , angiogenesis , tissue microarray , medicine , oncology , pathology , gene expression , gene , genetics
Endometrial cancer is one of the most common gynecological cancer in the developed countries and occurs mainly in postmenopausal women. Angiogenesis is important for cancer formation as it provides nutrients for growing tumor mass. Most tumors do not show detectable Homeobox A5 (HOXA5 level), suggesting its potential role as a cancer suppressor. It was demonstrated that HOXA5 is involved in the progression of various types of cancer and the loss of its expression correlates with higher pathological grade and poorer outcome.