Open AccessMetabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters
Author(s) -
Slobodan Rendić,
F. Peter Guengerich
Publication year - 2020
Publication title -
current drug metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 106
eISSN - 1875-5453
pISSN - 1389-2002
DOI - 10.2174/1389200221999201208211537
Subject(s) - chloroquine , pharmacology , hydroxychloroquine , cytochrome p450 , in vivo , cyp2c19 , cyp2d6 , drug , cyp3a4 , transporter , drug metabolism , adme , drug interaction , enzyme , chemistry , biology , medicine , biochemistry , malaria , immunology , disease , covid-19 , microbiology and biotechnology , gene , infectious disease (medical specialty)
In clinical practice, chloroquine and hydroxychloroquine are often co-administered with other drugs in the treatment of malaria, chronic inflammatory diseases, and COVID-19. Therefore, their metabolic properties and the effects on the activity of cytochrome P450 (P450, CYP) enzymes and drug transporters should be considered when developing the most efficient treatments for patients.