Open AccessA Role for the Adenosine ADORA2B Receptor in Midazolam Induced Cognitive Dysfunction
Author(s) -
Jennifer Gile,
Yoshimasa Oyama,
Sydney Shuff,
Tobias Eckle
Publication year - 2020
Publication title -
current pharmaceutical design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 159
eISSN - 1873-4286
pISSN - 1381-6128
DOI - 10.2174/1381612826666200415171622
Subject(s) - spontaneous alternation , hippocampal formation , hippocampus , agonist , psychology , neuroscience , midazolam , pharmacology , medicine , receptor , sedation
We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hypothesized that hippocampal ADORA2B is crucial for cognitive function.