Open AccessDevelopment of a Novel Oral Delivery Vehicle for Probiotics
Author(s) -
Kevin Enck,
Surya R. Banks,
Hariom Yadav,
Mark E. Welker,
Emmanuel C. Opara
Publication year - 2020
Publication title -
current pharmaceutical design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 159
eISSN - 1873-4286
pISSN - 1381-6128
DOI - 10.2174/1381612826666200210111925
Subject(s) - regenerative medicine , drug delivery , in vivo , delivery system , gastric fluid , chemistry , medicine , pharmacology , cell , biology , microbiology and biotechnology , biochemistry , organic chemistry , chromatography
There is a significant interest in effective oral drug delivery of therapeutic substances. For probiotics, there is a particular need for a delivery platform that protects the bacteria from destruction by the acidic stomach while enabling targeted delivery to the intestine where microbiota naturally reside. The use of probiotics and how they impact the gut microbiota is a growing field and holds promise for the treatment of a variety of gastrointestinal diseases, including irritable bowel disease Crohn's disease and C. diff and other diseases, such as obesity, diabetes, Parkinson's, and Alzheimer's diseases.