Open AccessA clinical importance of natriuretic peptides in pediatric practice
Author(s) -
Е. В. Саперова,
И. В. Вахлова
Publication year - 2017
Publication title -
patologiâ krovoobraŝeniâ i kardiohirurgiâ/patologiâ krovoobrašeniâ i kardiohirurgiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.136
H-Index - 3
eISSN - 2500-3119
pISSN - 1681-3472
DOI - 10.21688/1681-3472-2017-1-117-127
Subject(s) - medicine , natriuretic peptide , heart failure , heart disease , hormone , cardiology , endocrinology
Natriuretic peptides (NUP) are peptide hormones secreted by cardiomyocytes in response to a volume overload of the heart. Emphasis in the article is placed on the history of NUP discovery, their chemical structure and pathophysiological mechanisms of action. The data on determination of NUP reference values in children with cardiac pathologies are analyzed. A NUP clinical significance in early diagnosis of heart failure in children, including those with congenital heart defects is shown. Also considered is NUP dynamics after surgical correction of congenital heart defects. A conclusion is drawn that NUP play an important prognostic role in evaluating early and late postoperative periods and disease outcomes on a whole. Received 11 October 2016. Accepted 22 December 2016. Funding: The study had no sponsorship. Conflict of interest: The authors declare no conflict of interest. Author contributions All authors contributed equally at all stages of the research.