Open AccessPersistent multiorgan failure
Author(s) -
Григорьев Евгений Валерьевич,
Плотников Георгий Павлович,
Шукевич Дмитрий Леонидович,
Головкин Алексей Сергеевич
Publication year - 2015
Publication title -
patologiâ krovoobraŝeniâ i kardiohirurgiâ/patologiâ krovoobrašeniâ i kardiohirurgiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.136
H-Index - 3
eISSN - 2500-3119
pISSN - 1681-3472
DOI - 10.21688/1681-3472-2014-3-82-86
Subject(s) - medicine , myelopoiesis , systemic inflammatory response syndrome , multiorgan failure , pathological , pathophysiology , autophagy , critically ill , organ dysfunction , immunology , intensive care medicine , pathology , sepsis , biology , haematopoiesis , apoptosis , biochemistry , genetics , stem cell
Persistent multiple organ failure is a topical and relatively common problem in critically ill patients. We summarize the pathophysiological characteristics of this syndrome, namely the ratio of pro-and antiinflammatory components of the systemic inflammatory response, the formation of immune suppression and catabolism, pathological myelopoiesis, autophagy. The clinical and laboratory characteristics of probable diagnostics and the principal directions of intensive therapy are given.