Open AccessSensitivity of enterobacteriaceae isolated from cardiosurgical patients to antimicrobial chemotherapy
Author(s) -
V. N. Ilina,
A. I. Subbotovskaya,
V. S. Kozyreva,
D. S. Sergeevichev,
A. N. Shilova
Publication year - 2015
Publication title -
patologiâ krovoobraŝeniâ i kardiohirurgiâ/patologiâ krovoobrašeniâ i kardiohirurgiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.136
H-Index - 3
eISSN - 2500-3119
pISSN - 1681-3472
DOI - 10.21688/1681-3472-2013-3-40-44
Subject(s) - ertapenem , netilmicin , meropenem , imipenem , enterobacteriaceae , microbiology and biotechnology , cephalosporin , klebsiella pneumoniae , amikacin , antibiotics , medicine , biology , antibiotic resistance , gentamicin , escherichia coli , tobramycin , biochemistry , gene
Data on the sensitivity of enterobacteriaceae isolated from cardiosurgical patients over a period from 2011 to 2012 are analysed in the paper. We studied 124 strains of enterobacteriaceae; the proportion of strains ESBL-producing CTX-M-type was 62.1%. It was found out that from 76.6% to 100% of enterobacteriaceae strains were insensitive to cephalosporins IIIIV generation, 62.0% to 72.7% of them were insensitive to the combinations of beta-lactams/beta-lactam inhibitors and 70.1% were insensitive to fluoroquinolones, with high susceptibility to carbapenems (90.9% to ertapenem, imipenem and meropenem 94.8%) and moderate one to aminoglycosides (amikacin 77.9%, netilmicin 72.7%). The reduction of sensitivity to carbapenems is determined by the occurrence of K.pneumoniae, with MIC of ertapenem varying from 2 to 16 ug/ml, MIC of meropenem ranging from 4 to 8 g/ml and MIC of imipenem being equal to 4 ug/ml.