Open AccessEfficacy of G-CSF mobilization CD34+ progenitor cells depending on ischemic history and age of patients with chronic heart failure
Author(s) -
I. I. Kim,
О. В. Повещенко,
В. И. Коненков,
Ye. A. Pokushalov,
А. Б. Романов,
Н. А. Бондаренко,
А. Ф. Повещенко,
David Sergeevichev,
Aleksandr Karaskov
Publication year - 2018
Publication title -
patologiâ krovoobraŝeniâ i kardiohirurgiâ/patologiâ krovoobrašeniâ i kardiohirurgiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.136
H-Index - 3
eISSN - 2500-3119
pISSN - 1681-3472
DOI - 10.21688/1681-3472-2012-1-75-78
Subject(s) - cd34 , medicine , granulocyte colony stimulating factor , progenitor cell , mobilization , heart failure , basal (medicine) , myocardial infarction , peripheral blood , peripheral , bone marrow , cardiology , granulocyte , stem cell , chemotherapy , biology , microbiology and biotechnology , history , archaeology , insulin
It is shown that administration of G-CSF (Granulocyte Colony Stimulating Factor) to patients with chronic heart failure has a gematologic effect, while increasing the number of leukocytes and neutrophils in the peripheral blood. G-CSF leads to mobilization of progenitor cells (PCs) from the bone marrow into the peripheral blood. The basal content of CD34+ cells, the number of heart attacks and the time period from the last myocardial infarction effect the number of CD34+ cells after mobilization.