Open AccessTreatment of acute lymphoblastic leukemia in children by ALL IC-BFM 2002 protocol: results of multicenter retrospective study
Author(s) -
Т. Т. Валиев,
М. А. Шервашидзе,
И. В. Осипова,
Т. И. Бурлуцкая,
Н. А. Попова,
Н. С. Осмульская,
Г. А. Алескерова,
С. Л. Сабанцев,
З. С. Гордеева,
Н. А. Батманова,
М. Р. Тренина,
Д. В. Бирлюкова,
К. И. Киргизов,
С. Р. Варфоломеева
Publication year - 2021
Publication title -
rossijskij žurnal detskoj gematologii i onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-5496
pISSN - 2311-1267
DOI - 10.21682/2311-1267-2021-8-3-59-70
Subject(s) - medicine , protocol (science) , christian ministry , lymphoblastic leukemia , multicenter study , retrospective cohort study , pediatrics , overall survival , pediatric oncology , leukemia , randomized controlled trial , cancer , alternative medicine , pathology , philosophy , theology
By the whole history of pediatric acute lymphoblastic leukemia (ALL) treatment protocols development, one of the World ideologist of original science-based therapeutic approaches was German group BFM (Berlin–Frankfurt–Münster). It is not surprisingly that modern ALL treatment protocols, developed by BFM group are high-effective and use in many countries. Understanding the probability of recovery of overwhelming ALL patients majority treated by ALL IC-BFM 2002 protocol, the Scientific-Practical Board of Ministry of Health of Russia in 2020 adopted a protocol as clinical recommendation for pediatric ALL treatment (ID:529). It the current issue BFM ALL treatment protocols evolution is presented and first Russian multicenter experience in pediatric ALL treatment by ALL IC-BFM 2002 protocol. It was 408 pediatric and adolescents patients with primary ALL included the study. All of them were treated by ALL IC-BFM 2002 protocol from 01.11.2003 to 12.05.2021. Survival rate was estimated on 01.06.2021. ALL IC-BFM 2002 demonstrated a high efficiency in multicenter retrospective study. 15-year event-free survival was 83.7 ± 2.1 %, relapsefree survival – 88 ± 1.8 % and overall survival – 93.4 ± 1.4 %. So, ALL IC-BFM 2002 protocol could be realized in Russian clinics and give results similar to world’s leading medical centers.