Open AccessVeno-occlusive liver disease after hematopoietic stem cell transplantation and high-dose chemotherapy regimens. Literature review
Author(s) -
А. О. Костарева,
Е. Б. Мачнева,
Н. В. Сидорова,
К. И. Киргизов
Publication year - 2020
Publication title -
rossijskij žurnal detskoj gematologii i onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-5496
pISSN - 2311-1267
DOI - 10.21682/2311-1267-2020-7-3-94-101
Subject(s) - hepatic veno occlusive disease , medicine , hematopoietic stem cell transplantation , chemotherapy , stem cell , disease , incidence (geometry) , transplantation , toxicity , haematopoiesis , oncology , surgery , gastroenterology , intensive care medicine , physics , biology , optics , genetics
Veno-occlusive liver disease (VOD), now more often referred to as “sinusoidal obstruction syndrome” (SOS), is a symptom complex that develops in the early stages after hematopoietic stem cell transplantation and some chemotherapy regimens due to the toxicity of a number of drugs used and accompanied by the following symptoms: hyperbilirubinemia, fluid retention, weight gain, and painful hepatomegaly. According to various sources, the incidence of SOS/VOD in patients with oncohematological profile ranges from 3 to 15 %. At present, the standard schemes for the prevention of this condition are not fully recommended. The article presents a brief review of the literature, representing international experience in the study and treatment of SOS/VOD.