Open AccessThrombotic microangiopathy associated with hematopoietic stem cell transplantation: general characteristics and an example from clinical practice
Author(s) -
Е. Б. Мачнева,
М. А. Болохонова,
Т. З. Алиев,
Д. В. Шевцов,
А. М. Сулейманова,
Н. В. Сидорова,
Evgenii A. Osmanov,
К. И. Киргизов
Publication year - 2020
Publication title -
rossijskij žurnal detskoj gematologii i onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-5496
pISSN - 2311-1267
DOI - 10.21682/2311-1267-2020-7-3-86-93
Subject(s) - thrombotic microangiopathy , microangiopathic hemolytic anemia , hematopoietic stem cell transplantation , pathogenesis , medicine , calcineurin , transplantation , microangiopathy , stem cell , immunology , platelet , thrombotic thrombocytopenic purpura , disease , diabetes mellitus , biology , endocrinology , genetics
Associated hematopoietic stem cell transplantation (HSCT) or transplant-associated thrombotic microangiopathy (TA-TMA) is currently a generally recognized and severe complication of HSCT with a high risk of mortality. TMA is characterized by microangiopathic hemolytic anemia and thrombocytopenia, resulting in the accumulation of platelets in the microvasculature, which leads to dysfunction of the ischemic organ. The pathogenesis of TА-TMA is based on endothelial damage by various trigger factors (in particular, chemotherapeutic agents in the conditioning regimen, the use of calcineurin inhibitors, alloreactivity, infectious agents). The article presents the peculiarities of terminology, pathogenesis and clinical manifestations of TA-TMA, methods of therapy for this pathology. Examples of management of patients with TA-TMA are demonstrated using a clinical example.