Open AccessDiagnosis and treatment of post-transfusion iron overload in pediatric hematology: literature review
Author(s) -
Н. А. Батманова,
Т. Т. Валиев,
К. И. Киргизов,
С. Р. Варфоломеева
Publication year - 2020
Publication title -
rossijskij žurnal detskoj gematologii i onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-5496
pISSN - 2311-1267
DOI - 10.21682/2311-1267-2020-7-3-70-77
Subject(s) - medicine , hematology , haematopoiesis , chelation therapy , intensive care medicine , blood transfusion , transfusion therapy , thalassemia , stem cell , biology , genetics
Packed red blood cells are important part of modern treatment recommendations of anemic syndrome in benign and malignant diseases of hematopoietic system in both adults and children. Special features of iron metabolism in the human body after erythrocytes-containing transfusions lead to its increased accumulation in organs and tissues and post-transfusion iron overload development. Clinical manifestation of post-transfusion iron overload varies, but in the absence of chelation therapy can lead to life-threatening complications. This literature review describes the main causes of iron overload, clinical features, and diagnosis and treatment of iron overload.