Open AccessChronic “graft versus host” disease after allogeneic hematopoietic stem cell transplantation: basic characteristics, pathogenetic mechanisms, treatment strategies and problems of clinical practice
Author(s) -
Е. Б. Мачнева,
В. Ю. Панарина,
Т. З. Алиев,
Д. В. Шевцов,
А. М. Сулейманова,
В.В. Константинова,
А. Е. Буря,
Н. Г. Степанян,
Ю. В. Скворцова,
Н. В. Сидорова,
Evgenii A. Osmanov,
К. И. Киргизов,
С. Р. Варфоломеева
Publication year - 2020
Publication title -
rossijskij žurnal detskoj gematologii i onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-5496
pISSN - 2311-1267
DOI - 10.21682/2311-1267-2020-7-2-94-111
Subject(s) - hematopoietic stem cell transplantation , graft versus host disease , medicine , disease , immunology , transplantation , stem cell , pathogenesis , intensive care medicine , hematopoietic cell , hematopoietic stem cell , haematopoiesis , biology , genetics
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for different spectrum of diseases. This type of treatment is constantly improving, but HSCT remains a risky procedure with various possible complications, the main is – chronic “graft versus host” disease (cGVHD). сGVHD is immune disregulation, and characterized by a variety of clinical manifestations that reflect the multiple underlying pathophysiology mechanisms. The study of cGVHD has now made great progress, but there’s still a lot of questions. General characteristics, risk-factors of development, clinical manifestations, pathogenesis of cGVHD will be discussed in this article. Clinical case presented in this article explains usage of basic and novel agents for cGVHD treatment, prevention criterions for treatment of cGVHD in children.