Open AccessRetinoblastoma: a patient’s story
Author(s) -
А. А. Яровой,
Т.Л. Ушакова,
О. В. Голубева,
И. А. Левашов,
С. Н. Михайлова,
В. А. Яровая,
В. Г. Поляков
Publication year - 2020
Publication title -
rossijskij žurnal detskoj gematologii i onkologii
Language(s) - English
Resource type - Journals
eISSN - 2413-5496
pISSN - 2311-1267
DOI - 10.21682/2311-1267-2020-7-2-134-9
Subject(s) - medicine , cryotherapy , retinoblastoma , enucleation , melphalan , brachytherapy , vitreous hemorrhage , surgery , chemotherapy , external beam radiotherapy , radiation therapy , vitrectomy , ophthalmology , visual acuity , biochemistry , chemistry , gene
Relevance. Development and application of novel treatment methods for patients with retinoblastoma (Rb) is a great task since it may provide higher rates of eye salvage and reduce adverse effects of current therapy. Aim of the study was to represent the history of Rb eye-sparing treatment in Russia and worldwide through the one clinical case. Materials and methods. A child was treated by systemic chemotherapy, plaque brachytherapy using non-described techniques, cryotherapy and external beam radiotherapy. Intravitreal chemotherapy was approached for treatment of vitreous seeding. Vitreoretinal surgery with melphalan irrigation was successfully performed after failure of vitreous hemorrhage conservative treatment and parents’ refusal to indicated enucleation. The child died from CNS disseminated esthesioneuroblastoma. Results. The use of various treatment modalities helped to save the single eye. Conclusions. Intravitreal chemotherapy was introduced in Russia for the first time. Performed vitreoretinal surgery with melphalan irrigation was proved to be a safe and effective technique in case of vitreous hemorrhage in the eye with Rb. External beam therapy is associated with fatal second tumors development.