Open AccessClinical Laboratory Markers in COVID-19
Author(s) -
Mohammad Zahidul Iqbal,
Benazeer Zohra
Publication year - 2022
Publication title -
annals of king edward medical university
Language(s) - English
Resource type - Journals
eISSN - 2079-7192
pISSN - 2079-0694
DOI - 10.21649/akemu.v27i4.4907
Subject(s) - medicine , disease , intensive care medicine , pandemic , covid-19 , medline , immune system , bone marrow , mortality rate , bioinformatics , immunology , pathology , infectious disease (medical specialty) , political science , law , biology
Background: The causative agent of the present COVID-19 pandemic is a novel RNA virus called SARS CoV-2. Clinical laboratory has a central role in the diagnosis, prognosis, and predicting the progression of the disease. Several hematological, biochemical, immunological, and coagulation parameters change during the course of the disease. Based on the information from several studies, it is presumed that virus replication alters the immune system of the body. These alterations cause cellular damage in various organs like the lungs, liver, heart, and bone marrow. Ultimately, it may lead to multi-organ failure and death. Methods: An internet search in Medline, PubMed, Scopus, and Scholarly articles was performed. Studies reporting on changes in laboratory parameters in COVID-19 were selected, data extracted, and analyzed. Conclusion: Laboratory markers are helpful in the diagnosis of cases and more importantly, to identify those patients where chances of disease progression to severity are present. This will not only reduce the burden on the
health care system but also reduce the mortality rate by channelizing resources to those cases who need critical care and management.