Open AccessComparison of Retinal Nerve Fiber Layer Thickness Changes after Intravitreal Bevacizumab in Patients of Diabetic Macular Edema
Author(s) -
Muhammad Shaheer,
Asad Aslam Khan,
Nasir Ahmed,
Tehseen Mahju,
Ummarah Rasheed
Publication year - 2018
Publication title -
annals of king edward medical university
Language(s) - English
Resource type - Journals
eISSN - 2079-7192
pISSN - 2079-0694
DOI - 10.21649/akemu.v24i1.2320
Subject(s) - medicine , nerve fiber layer , retinal , ophthalmology , bevacizumab , diabetic macular edema , glaucoma , edema , macular edema , diabetic retinopathy , diabetes mellitus , surgery , chemotherapy , endocrinology
Diabetic macular edema is one of the leading causes of visual loss in diabetic patients. However, the impact of medicinal treatment on the occurrence of macular edema remained elusive. Objectives: This study was designed to determine the effect of intravitreal bevacizumab in patients of diabetic macular edema.Methods: An interventional study was conducted on patients that underwent pre-injection and one-month post-injection OCT for RNFL thickness. OCT was performed by researchers and findings were recorded accordingly. The retinal nerve fiber layer thickness was measured in superior, inferior halves and total average thickness. Pre- and post-injection OCT were conduced and macular thickness were documented. Results: The mean retinal nerve fiber layer thickness was decreased in superior and inferior halves as well as in the total thickness. Conclusion: Intra vitreal bevacizumab decreases the retinal nerve fiber layer thickness. Large randomized controlled trials are required to establish or rule out any association between this decrease in thickness and incidence if glaucoma in such patients.