Open AccessEvaluation of the effectiveness of pharmacological correction of experimental osteoporosis by glucosamine sulfate, strontium chloride, and their combination
Author(s) -
Aleksandr V. Anikanov,
E. B. Artyushkova,
А В Файтельсон,
Densingh Samuel Raj Rajkumar
Publication year - 2020
Publication title -
čelovek i ego zdorovʹe
Language(s) - English
Resource type - Journals
eISSN - 1998-5754
pISSN - 1998-5746
DOI - 10.21626/vestnik/2020-2/07
Subject(s) - strontium chloride , strontium , osteoporosis , glucosamine , densitometry , medicine , bone density , chemistry , endocrinology , biomedical engineering , biochemistry , organic chemistry
Objective. To study the osteoprotective activity of glucosamine sulfate, strontium chloride, and their combinations on a model of experimental osteoporosis in laboratory animals (OVX model) in comparison with the Strometta preparation and control (OVX without correction). Materials and methods. The material for the study was female Wistar rats weighing 250 ± 30 g. To simulate osteoporosis, bilateral ovariectomy was performed. Microcirculation was evaluated by Doppler flowmetry. Digital X-ray densitometry was used to determine bone density. Using histological morphometry, the transverse size of the trabeculae of the spongy bone tissue was studied. Results. In such parameters as bone density, microcirculation, and the average width of bone trabeculae, significant differences were established compared with the control (OVX without correction) for groups with correction of glucosamine sulfate, strontium chloride, and their combination, and thus their osteoprotective effect was confirmed. Conclusion. In the future, glucosamine sulfate, strontium chloride, and their combination can be used for drug prevention of osteoporosis in the postmenopausal period. However, for the introduction of strontium chloride and its combination with glucosamine sulfate into clinical practice, it is necessary to conduct complete preclinical and clinical trials.