Open AccessИЗУЧЕНИЕ ГЕМОСТАТИЧЕСКОЙ АКТИВНОСТИ КРОВООСТАНАВЛИВАЮЩИХ ИМПЛАНТОВ В ЭКСПЕРИМЕНТЕ IN VITRO
Author(s) -
В. А. Липатов,
K.A. Sotnikov,
Д. А. Северинов,
М. В. Косоголов,
С. Г. Писковитина,
С. Ю. Гладнева,
С. Э. Малетин
Publication year - 2019
Publication title -
innova
Language(s) - English
Resource type - Journals
ISSN - 2500-2937
DOI - 10.21626/innova/2019.4/01
Subject(s) - hemostatic agent , carboxymethyl cellulose , coagulation , medicine , hemostasis , hemostatics , surgery , pharmacology , chemistry , sodium , organic chemistry
Stopping bleeding during injuries, planned and emergency surgical interventions is a difficult and not completely resolved problem. Accordingly, in modern surgery, the most promising direction is the development of new drugs that affect the hemostatic system and locally acting hemostatic agents. This article presents the results of the research on the comparative analysis of the ability of application hemostatic agents to form a blood clot in the in vitro experiment. The hemostatic properties of the following agents were studied: sponge implants based on sodium salt of carboxymethyl cellulose in two versions: unmodified and thermostabilized, hemostatic collagen sponge, and «Tachocomb» hemostatic sponge. The experiment was performed using stabilized blood citrate of 10 volunteer donors, which was recalcification subsequently, on an APG2-02-P coaguometer. In this research, we confirmed the effectiveness of this technique for the comparative analysis of hemostatic implants. In addition, the results of the research showed that all the samples used by us significantly reduce the coagulation time in the experiment compared with the control.