Open AccessDoes the Modification of Starting Gonadotropin Dose During ICSI Cycle Have Any Significant Impact on Cycle Outcome?
Author(s) -
Enis Özkaya,
Yavuz Şahin,
S Eser,
Betül Albayrak,
Oğuzhan Bulduk,
İlhan Şanverdi,
Tayfun Kutlu
Publication year - 2017
Publication title -
gynecology obstetrics and reproductive medicine
Language(s) - English
Resource type - Journals
ISSN - 2602-4918
DOI - 10.21613/gorm.2016.651
Subject(s) - gonadotropin , intracytoplasmic sperm injection , antral follicle , medicine , andrology , oocyte , pregnancy , human chorionic gonadotropin , endocrinology , follicle stimulating hormone , pregnancy rate , hormone , biology , luteinizing hormone , in vitro fertilisation , embryo , genetics , microbiology and biotechnology
OBJECTIVE: The aim of this study was to figure out the impact of gonadotropin dose alteration requirements due to high response or unresponsiveness on intracytoplasmic sperm injection cycle outcomes in a standard group of patients.STUDY DESIGN: One hundred cycles with same gonadotropin dosage along the stimulation were compared with 100 cycles in which gonadotropin dose alterations were needed due to high response or unresponsiveness. Groups were compared in terms of age, body mass index, serum follicle stimulating hormone and estradiol levels, antral follicle count, gonadotropin dosage, duration of stimulation, endometrial thickness at trigger day, number of total, mature and immature oocytes and finally the clinical pregnancy rates.RESULTS: There were significant differences between groups with regard to gonadotropin starting dose, total gonadotropin dose, duration of stimulation, estradiol level at trigger day, number of total oocytes and metaphase 1 oocyte number. Clinical pregnancy rates were similar between groups.CONCLUSION: Dose alteration requirement along intracytoplasmic sperm injection cycle result in high number of total and metaphase 1 oocyte yields, higher starting gonadotropin and total gonadotropin dose, duration of stimulation and estradiol level at trigger day, however clinical pregnancy rates were similar between groups.