Open AccessNanostructured Insecticide Composition through the Incorporation of Natural Abamectin in β-Cyclodextrin: Activity against Aedes aegypti Larvae
Author(s) -
Vanessa Cristina Estevam Bittencourt,
Ana Maria Santos Moreira,
Alexandre A Ferreira,
Erúzia A. E Ferreira,
Antônio F. F Gomides,
Cibele Isaac Saad Rodrigues,
Gustavo Ferreira Martins,
Jéferson G. Da Silva,
Keyller Bastos Borges,
Ângelo Márcio Leite Denadai
Publication year - 2021
Publication title -
journal of the brazilian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.337
H-Index - 70
eISSN - 1678-4790
pISSN - 0103-5053
DOI - 10.21577/0103-5053.20210093
Subject(s) - isothermal titration calorimetry , chemistry , cyclodextrin , aedes aegypti , supramolecular chemistry , aqueous solution , zeta potential , nuclear chemistry , organic chemistry , larva , molecule , materials science , nanotechnology , nanoparticle , botany , biology
This study searched for a new pre-formulation based on the natural compound from the class of the avermectins, named abamectin (ABA), in order to improve its action against Aedes aegypti larvae by complexation with β-cyclodextrin (βCD). Concerning the low aqueous solubility of ABA, even in the presence of βCD, it was also invoked the strategy of working with hydrophobic nanoprecipitates (HNPs). For these purposes, molecular and supramolecular characterizations of 1:1 ABA/βCD complex and evaluation of its toxicity against A. aegypti larvae were performed. In the physical-chemistry characterizations, changes in the infrared spectra and thermal profiles in relation to precursors confirmed the occurrence of interactions between ABA and βCD in solid state. Nuclear magnetic resonance (NMR) data suggest the inclusion of ABA in βCD via benzofuran ring. Isothermal titration calorimetry (ITC) experiments allowed to verify the formation of complex with a 1:1 stoichiometry, which was entropy driven. The dynamic light scattering and zeta potential data from inclusion compounds demonstrated changes in the size of the ABA/βCD HNP if compared with the ABA HNP. Finally, the results for biological assays demonstrate that the strategy to prepare the inclusion compound led to an increase in the larvicidal activity in relation to free ABA.