Open AccessARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL
Author(s) -
Ramón de Oliveira,
Luiza Cruz,
Luiz Alberto Vieira Dias
Publication year - 2022
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.21577/0100-4042.20170888
Subject(s) - artemisinin , artemisia annua , natural product , sesquiterpene , malaria , industrial production , plasmodium falciparum , chemistry , stereochemistry , biology , economics , keynesian economics , immunology
ARTEMISININ AND DERIVATIVES: DISCOVERY, SYNTHETIC STRATEGIES, AND INDUSTRIAL PRODUCTION. Artemisinin, a natural sesquiterpene isolated from the Artemisia annua L. plant, represents a remarkable achievement in the treatment against malaria. Since its discovery in the 1970’s, researchers readily started synthesizing this complex natural product containing an unusual endoperoxide fragment. Despite various total syntheses reported, only in the last decade the production jumped from extraction/bench scale to industrial manufacturing. In this sense, the objective of this contribution is to highlight the discovery, the most representative works towards the synthesis of artemisinin and its main derivatives used worldwide against malaria, and the path to the industrial production of these compounds.