Open AccessELECTROSPINNING PBAT (POLY (BUTYLENE-ADIPATE-CO-TEREPHTHALATE))/PCL (POLY(ε-CAPROLACTONE) BLEND CONTAINING PROPOLIS FOR THE PREPARATION OF A SMART WOUND DRESSING
Author(s) -
Heloisa G. Zanella,
Ariane R. de S. Rossin,
Janice Caroline Hardt,
Andressa Giombelli Rosenberger,
Juliana C. Wiggers,
Josiane Caetano,
Douglas Cardoso Dragunski
Publication year - 2021
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.21577/0100-4042.20170787
Subject(s) - electrospinning , propolis , adipate , differential scanning calorimetry , materials science , fourier transform infrared spectroscopy , caprolactone , polymer , nanofiber , antimicrobial , contact angle , chemical engineering , fiber , scanning electron microscope , polymer blend , polymer chemistry , composite material , chemistry , organic chemistry , food science , copolymer , physics , engineering , thermodynamics
The electrospinning has been widely used in tissue engineering for the preparation of wound dressing with the most varied polymers and drugs. Considering that propolis has antimicrobial and anti-inflammatory characteristics, the aim was to develop electrospun fibers from PBAT (poly (butylene-adipate-co-terephthalate)/PCL (poly(e-caprolactone) containing propolis in order to promote antimicrobial action and the healing of wounds. By the optical microscopy analysis, the best parameter for obtaining the fibers was chosen: 16.5% (v/v) of propolis extract alcoholic solution, 14.0 cm needle-collector distance, 17.0 kV of voltage and 0.5 mL h-1 flow rate. The scanning electron microscopy demonstrated fiber diameters of 0.51 ± 0.12 μm for the polymer blend and 1.16 ± 0.98 μm for the blend with propolis. The Fourier transform infrared spectroscopy (FTIR) results showed no evidence of chemical interaction with propolis, this being a physical interaction. This interaction was corroborated by the differential scanning calorimetry (DSC) due to the variation in the heats involved, mainly in the aromatic part of the polymer blend, indicating a better interaction in the PBAT group. Finally, it was found that fibers presents propolis antimicrobial activity against the bacteria Pseudomonas Aeruginosa. The results indicate that this blend has a great potential to be used as a cutaneous dressing.