ELECTROSPINNING PBAT (POLY (BUTYLENE-ADIPATE-CO-TEREPHTHALATE))/PCL (POLY(ε-CAPROLACTONE) BLEND CONTAINING PROPOLIS FOR THE PREPARATION OF A SMART WOUND DRESSING | Zendy

Heloisa G. Zanella | Zendy; Ariane R. de S. Rossin | Zendy; Janice Caroline Hardt | Zendy; Andressa Giombelli Rosenberger | Zendy; Juliana C. Wiggers | Zendy; Josiane Caetano | Zendy; Douglas Cardoso Dragunski | Zendy

Open Access

ELECTROSPINNING PBAT (POLY (BUTYLENE-ADIPATE-CO-TEREPHTHALATE))/PCL (POLY(ε-CAPROLACTONE) BLEND CONTAINING PROPOLIS FOR THE PREPARATION OF A SMART WOUND DRESSING

Author(s) -

Heloisa G. Zanella,

Ariane R. de S. Rossin,

Janice Caroline Hardt,

Andressa Giombelli Rosenberger,

Juliana C. Wiggers,

Josiane Caetano,

Douglas Cardoso Dragunski

Publication year - 2021

Publication title -

química nova

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.214

H-Index - 73

eISSN - 1678-7064

pISSN - 0100-4042

DOI - 10.21577/0100-4042.20170787

Subject(s) - electrospinning , propolis , adipate , differential scanning calorimetry , materials science , fourier transform infrared spectroscopy , caprolactone , polymer , nanofiber , antimicrobial , contact angle , chemical engineering , fiber , scanning electron microscope , polymer blend , polymer chemistry , composite material , chemistry , organic chemistry , food science , copolymer , physics , engineering , thermodynamics

The electrospinning has been widely used in tissue engineering for the preparation of wound dressing with the most varied polymers and drugs. Considering that propolis has antimicrobial and anti-inflammatory characteristics, the aim was to develop electrospun fibers from PBAT (poly (butylene-adipate-co-terephthalate)/PCL (poly(e-caprolactone) containing propolis in order to promote antimicrobial action and the healing of wounds. By the optical microscopy analysis, the best parameter for obtaining the fibers was chosen: 16.5% (v/v) of propolis extract alcoholic solution, 14.0 cm needle-collector distance, 17.0 kV of voltage and 0.5 mL h-1 flow rate. The scanning electron microscopy demonstrated fiber diameters of 0.51 ± 0.12 μm for the polymer blend and 1.16 ± 0.98 μm for the blend with propolis. The Fourier transform infrared spectroscopy (FTIR) results showed no evidence of chemical interaction with propolis, this being a physical interaction. This interaction was corroborated by the differential scanning calorimetry (DSC) due to the variation in the heats involved, mainly in the aromatic part of the polymer blend, indicating a better interaction in the PBAT group. Finally, it was found that fibers presents propolis antimicrobial activity against the bacteria Pseudomonas Aeruginosa. The results indicate that this blend has a great potential to be used as a cutaneous dressing.

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