Open AccessSIMETRIA MOLECULAR E REAÇÕES DE DESSIMETRIZAÇÃO EM SÍNTESE ORGÂNICA#
Author(s) -
Bruno Matos Paz,
Emílio C. de Lucca,
Ronaldo Aloise Pilli
Publication year - 2021
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.21577/0100-4042.20170760
Subject(s) - desymmetrization , organocatalysis , organic synthesis , chemistry , combinatorial chemistry , biochemical engineering , nanotechnology , organic chemistry , catalysis , enantioselective synthesis , materials science , engineering
MOLECULAR SYMMETRY AND DESYMMETRIZATION REACTIONS IN ORGANIC SYNTHESIS. Molecular Symmetry has found several applications in Organic Chemistry. The aim of this article is to showcase its relevance as a tool for synthetic planning. Natural Products and synthetic compounds with pharmaceutical applications were selected to highlight desymmetrization reactions that make use of organocatalysis, biocatalysis or by transition metals. The recognition of structural patterns in retrosynthetic analysis is discussed for compounds that exhibit explicit or hidden symmetry. Limitations of the aforementioned strategies are also described, as well as the untapped potential, challenges and frontiers yet to be explored regarding these concepts.