Open AccessTHE INFLUNECE OF 4G/5G POLYMORPHISM OF ACTIVATOR INHIBITOR PLASMINOGEN 1 GENE (PAI-1) ON DEVELOPEMENT DEEP VEIN THROMBOSIS
Author(s) -
Maja Pođanin,
Rifet Terzić,
Aldijana Avdić,
Amela Jusić
Publication year - 2020
Publication title -
human
Language(s) - English
Resource type - Journals
eISSN - 2232-996X
pISSN - 2232-9935
DOI - 10.21554/hrr.042006
Subject(s) - genotype , heterozygote advantage , polymorphism (computer science) , medicine , plasminogen activator inhibitor 1 , thrombosis , venous thrombosis , gastroenterology , plasminogen activator , deep vein , genotype frequency , gene , genetics , biology
Analysis of 4G/5G polymorphisms of PAI-1 gene in interaction with other genetic and external risk factors that induce development of venous thromboembolism can be used for risk assessment for development of venous thromboembolism. Research was conducted on 202 examinees of both genders, older than 18, from north-eastern Bosnia. Experimental group included 100 examinees with diagnosed DVT and 101 examinees who until the sampling procedure did not have diagnosed DVT. In DVT group, following genotype frequencies were determined: 27% of examinees had a normal genotype 5G/5G, 68% are heterozygotes and 5% are mutated homozygotes 4G/4G. In the control group, frequencies of 4G/5G polymorphisms of PAI-1 gene were: 42.6% of examinees have 5G/5G genotype, 55.4% are heterozygotes 4G/5G and 2% are 4G/4G genotype. Obtained results support the hypothesis that PAI-1 in interaction with other genetic and external risk factors probably induces the development of venous thromboembolism.