Open AccessProlonged reception of cholecalcipherol – the basis of effective prevention of hypovitaminosis D in young years
Author(s) -
И. Н. Захарова,
Leonid Klimov,
С. В. Долбня,
В А Курьянинова,
С. В. Мальцев,
С. И. Малявская,
А. В. Ягупова,
An. Tsutsaeva,
Е. А. Соловьёва,
Е В Голышева,
А. А. Дятлова,
A.A. Alkhimidi,
Ш. О. Кипкеев
Publication year - 2020
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2020-10-16-26
Subject(s) - vitamin d and neurology , hypovitaminosis , cholecalciferol , medicine , vitamin d deficiency , vitamin , croatian , gastroenterology , pediatrics , linguistics , philosophy
. Vitamin D plays a fundamental role in the regulation of calcium and phosphorus homeostasis, and in recent decades its non-calcemic effects have been intensively studied. The aim of the work was to analyze the patterns of vitamin D availability in young children against the background of prolonged use of an aqueous solution of cholecalciferol in preventive doses. Materials and methods : 192 children of the first three years of life were examined (Arkhangelsk – 77 (40.1%), Moscow – 38 (19.8%), Stavropol – 77 (40.1%) children). Assessment of vitamin D availability was carried out by the level of serum calcidiol (25(OH)D). Based on the initial vitamin D supply, patients were divided into groups, and participants used cholecalciferol preparations for 30 days. Results . The baseline vitamin D supply was 26.0 (19.5–35.4) ng/ml. Median 25(OH)D in children in the Moscow region is higher than in Arkhangelsk and Stavropol (p<0.0001). After using vitamin D in therapeutic doses, the median 25 (OH) D in Arkhangelsk was 46.7 (32.3–64.5) ng/ml, in Moscow – 52.6 (40.2–64.9) ng/ml, in Stavropol – 51.4 (41.3–69.8) ng/ml. According to the results of taking the prophylactic dose (1000 IU/day), satisfactory vitamin D was detected in 105 (54.7%) patients, insufficiency (from 20 to 30 ng/ml) – in 70 (36.5%), deficiency (from 10 up to 20 ng/ml) – in 17 (8.8%) children. Among children who had a 25(OH)D level of more than 30 ng/ml at the end of the study, the use of vitamin D preparations of 50–100 IU/kg and in 42 (41.0%) was effective in 62 (59.0%) children – in a dose of 100–150 IU/day, and in the group of patients with a level of 25(OH)D less than 30 ng/ml – a dose of 50 to 100 IU/kg was used in 69 (79.3%) patients, and a dosage of 100–150 IU/kg in only 18 (20.7%) children (p < 0.0005). Conclusion . The used prophylactic dosage of 1000 IU/day of an aqueous solution of cholecalciferol was effective in most compliance children. The elimination of deficiency and the prevention of vitamin D deficiency is most effective when used for 6 months or more.