Open AccessRole of metabolic glycemic control in programming perinatal risk in gestational diabetes
Author(s) -
Алиса Сергеевна Масель,
И. Л. Никитина,
Д. Я. Яблуновская,
В. Х. Текуева,
Polina Popova,
Ekaterina Kaprior,
Aleksandra Tkachuk,
Я.А. Болотько
Publication year - 2019
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2019-17-218-225
Subject(s) - glycemic , medicine , gestational diabetes , anthropometry , gestational age , body weight , birth weight , diabetes mellitus , endocrinology , zoology , gestation , pregnancy , biology , genetics
Purpose . Evaluate the effect of metabolic control of gestational diabetes mellitus (GDM) on the perinatal period course and anthropometric parameters of newborns. Materials and methods . 300 newborns were divided into 4 groups depending on the metabolic control of the mother. Group 1: fasting glycemia 5.3 mmol/L and> 7.8 mmol/L (n = 46), respectively; Group 4: control (n = 114). The analysis of the perinatal period course was carried out, the anthropometric parameters were estimated according to the tables INTERGROWTH-21st. Results . Differences in the frequency of obstetric injuries, which risk is associated with «above average» body weight of the newborn (p = 0.04), were found between the GDM group and the control group (38.7 and 12.3%, respectively, p = 0.5). The risk of having a baby with «above average» body weight (Group 1/Group 4, OR = 1.9, p = 0.1; Gr. 2/Gr. 4, OR = 2.6, and Gr. 3/Gr. 4, OR = 3.7, p <0.05), the ratio of weight/length (Gr. 1/Gr. 4, OR = 0.9, p = 0.9; Gr. 2/Gr. 4, OR = 3.6, and Gr. 3/Gr. 4, OR = 4.9, p <0.05) and head circumference (G.1/Gr. 4, OR = 1.1, p = 0.6; Gr. 2/Gr. 4, OR = 2.5, and Gr. 3/Gr. 4, OR = 2.9, p <0.05) was higher in Groups 2 and 3 than in Group 4. In the early neonatal period with GDM, hypoglycemia was more common than in the control Group 4. The lowest risk was in Group 1 (Gr. 1/Gr. 4, OR = 4.8; Gr. 2/Gr. 4, OR = 6.7; Gr. 3/Gr. 4, OR = 7.9, р < 0,05). Conclusions . Group 1 showed the lowest frequency and risk of adverse effects, which meets the control criteria of the Russian consensus.