Open AccessEffect of omeprazole on the hypotensive efficacy of amlodipine depending on the genetic characteristics of patients
Author(s) -
М. Н. Дорофеев,
Zhanna M. Sizova,
Е. В. Ших,
Natalya I. Lapidus,
К. А. Акмалова,
Н. П. Денисенко,
Elena A. Grishina,
Д. А. Сычев
Publication year - 2018
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2018-16-124-129
Subject(s) - medicine , blood pressure , cytochrome p450 , omeprazole , amlodipine , metabolism , endocrinology , cyp3a4 , pharmacology
Features of anti-hypertensive therapy amlodipiny at patients with the arterial hypertonia (AH) with comorbid pathology – kislotozavisimy diseases (KZZ), accepting омепразол, depending on genetic features of the patient are studied and analysed. It is shown that a certain genetic polymorphism of an isoenzyme of P450 3A4 cytochrome can shift a metabolism of an omeprazol towards P450 3A4 cytochrome and promote more expressed oppression of activity of this enzyme. Depending on rate of a metabolism at the sick AG and KZZ receiving a combination of an amlodipin and an omeprazol various anti-hypertensive effect of an amlodipin can be observed. Reliable differences in dynamics of indicators of daily monitoring of the arterial blood pressure (ABP) at sick AG - slow metabolizator and sick AG – fast and intermediate metabolizator are received. Decrease of the activity of an isoenzyme of P450 3A4 cytochrome at patients - slow metabolizator leads to retardation of a metabolism of an amlodipin and, as a result, to rising of its concentration in a blood plasma that is clinically shown by more expressed anti-hypertensive effect.