Open AccessTHE ROLE OF DYSLIPIDEMIA IN THE PROGRESSION OF DIABETIC RETINOPATHY
Author(s) -
А. Г. Кузьмин,
Sergey Andreevich Martynov,
М. В. Шестакова
Publication year - 2017
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2017-3-44-46
Subject(s) - medicine , dyslipidemia , diabetic retinopathy , vascular permeability , vascular endothelial growth factor , growth factor , diabetes mellitus , retinal , angiogenesis , blood–retinal barrier , vascular endothelial growth factor a , ophthalmology , endocrinology , vegf receptors , receptor
Angiogenesis factors, growth factors (vascular endothelial growth factor (VEGF), angiopoietin-2, insulin-like growth factor, etc.) and cytokines play the leading role in the production by endothelial cells of new retinal blood vessels, increased vascular permeability resulting in exudation and macular edema leading to the development of irreversible complications and vision loss. Although large-scale clinical trials demonstrated that tight control of glycemia and normalization of systemic blood pressure reduce the risk of progression of diabetic retinopathy (DR), the relationship between lipid disorders and retinal damage is not fully understood.