Open AccessСРАВНЕНИЕ ТОКОЛИЗА ГЕКСОПРЕНАЛИНОМ И АТОЗИБАНОМ
Author(s) -
О. Р. Баев,
О. Н. Васильченко,
А. О. Карапетян,
Н.К. Тетруашвили,
Zulfiya S. Khodzhaeva
Publication year - 2017
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2017-2-57-61
Subject(s) - medicine , gestation , pregnancy , obstetrics , tocolytic agent , gestational age , anesthesia , preterm labor , genetics , biology
The aim of the study was to compare the efficacy and safety of tocolytic agents - atosiban and hexoprenaline. Patients and methods: The study included 119 pregnant women with threatening preterm labour between 28 to 34 weeks of gestation. Sixty two pregnant received 62 tocolysis by hexoprenaline and fifty seven - atosiban. There were no differences in the clinical condition of pregnant women and features of preterm labour among groups before start of the tocolysis. The degree of effectiveness is determined by the duration of the pregnancy prolongation (48 hours, 7 days, more than 14 days). Results: 9 women of 62 that received hexoprenaline tocolysis (22,6%), and 2 – atosiban (3.5%) failed to prolong the pregnancy for more than 48 hours (p 0,05%). On average, atosiban tocolysis allowed to prolong pregnancy by 6.5 days longer than hexoprenaline (p < 0,05). Conclusion: The results of study has shown that atosiban is more effective than hexoprenaline in pregnancy prolongation for more than 48 hours in threatening preterm labor.