Open AccessChelation therapy in children
Author(s) -
Марина Красильникова
Publication year - 2016
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2016-1-123-127
Subject(s) - medicine , context (archaeology) , thalassemia , aplastic anemia , anemia , ineffective erythropoiesis , myelofibrosis , myelodysplastic syndromes , sideroblastic anemia , pediatrics , gastroenterology , erythropoiesis , bone marrow , biology , paleontology
Iron overload (RV) is a condition caused by excessive intake of iron, and in the absence of the specific mechanisms for its excretion - excessive accumulation in tissues and their subsequent lesion leading to functional organ failure [1]. This condition most commonly occurs as a result of regular replacement therapy with erythrocyte mass in the treatment of various anemias. According to statistics, about 500 sick children and 2 000 adults develops post-transfusion RV in Russia in every year [2]. It develops in the context of hereditary anemia (major and intermediate forms of beta-thalassemia, other hemoglobinopathies, severe membrane and enzyme defects, congenital sideroblastic and dyserythropoetic anemia, constitutional hypo- and aplastic anemia) or acquired diseases (acquired aplastic anemia, myelodysplastic syndrome (MDS), myelofibrosis, etc.). [3--5].