Open AccessThe genome-wide analysis of the vitamin D receptor binding sites evidences a wide range of potential therapeutic applications of vitamin D
Author(s) -
О. А. Громова,
И Ю Торшин,
В. Б. Спиричев
Publication year - 2016
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2016-1-12-21
Subject(s) - calcitriol receptor , computational biology , genome , vitamin , vitamin d and neurology , biology , human genome , receptor , bioinformatics , gene , genetics , biochemistry , endocrinology
The article presents the results of the genome-wide bioinformatic analysis of the vitamin D receptor interactions with the human genome DNA. Using a biological system assay, biological roles of proteins were analyzed that are specifically associated with the impact of VDR receptor. Systematization of the biological roles of vitamin D opens broad and previously unexplored perspectives for pediatric applications of vitamin D preparations for the prevention and treatment of a wide range of diseases starting from the fetal stage and early childhood.