Open AccessTreatment of acute lymphoblastic leukemia in children: a review of literature
Author(s) -
Г. А. Алескерова
Publication year - 2016
Publication title -
medicinskij sovet
Language(s) - English
Resource type - Journals
eISSN - 2658-5790
pISSN - 2079-701X
DOI - 10.21518/2079-701x-2016-1-1-16
Subject(s) - lymphoblastic leukemia , prednisolone , mercaptopurine , medicine , oncology , chemotherapy , intensive care medicine , leukemia
The article tells about the main stages of improving treatment regimens for acute lymphoblastic leukemia (ALL) in children, from monotherapy with prednisolone and 6-mercaptopurine to novel multicomponent risk-adapted chemotherapy protocols. The focus is on evaluating risk factors which varied with the expansion of knowledge about the molecular biological profile of ALL. Only the detailed analysis of the clinical and immunobiological characteristics of ALL allowed to develop novel, highly effective treatment schemes leading to recovery in over 80% of patients.