Open AccessImmune system in development and progression of viral myocardial damage
Author(s) -
И. М. Хегай,
I.I. Trunina,
Т. А. Чеботарева,
Г. К. Ходикян,
П.В. Шумилов
Publication year - 2021
Publication title -
rossijskij vestnik perinatologii i pediatrii
Language(s) - English
Resource type - Journals
eISSN - 2500-2228
pISSN - 1027-4065
DOI - 10.21508/1027-4065-2021-66-3-27-33
Subject(s) - immune system , immunology , disease , cytokine , dilated cardiomyopathy , cardiomyopathy , medicine , inflammation , immune dysfunction , pathology , heart failure , cardiology
This review demonstrates the role of the immune system in the development and progression of cardiac pathology caused by viral infection. The authors describe the role of lymphocytes (T- helper-17–Th17) in the viral persistence in myocardial tissue. They provide the information on increased level of interleukin-17A, the main Th17 cytokine in patients with dilated cardiomyopathy, which proves role of these cells in the progression of cardiac pathology. They discuss the role of T regulatory (Treg) lymphocytes in inflammatory heart disease.