Open AccessPediatric sepsis – time to reach agreement
Author(s) -
А. У. Лекманов,
П. И. Миронов
Publication year - 2020
Publication title -
rossijskij vestnik perinatologii i pediatrii
Language(s) - English
Resource type - Journals
eISSN - 2500-2228
pISSN - 1027-4065
DOI - 10.21508/1027-4065-2020-65-3-131-137
Subject(s) - sepsis , medicine , intensive care medicine , organ dysfunction , surviving sepsis campaign , severe sepsis , pediatrics , septic shock , immunology
Objective: to present the evolution and modern concept of pediatric sepsis. According to many authors, pediatric sepsis is considered to be the main cause of death from infectious diseases; and the mortality is associated with a late diagnosis and non-compliance with treatment guidelines. The article discusses the evolution of views on sepsis over the past 30 years. It analyzes the changes of sepsis concepts in adults from Sepsis-1 to Sepsis-3. Currently, sepsis is considered as a life-threatening organ dysfunction due to dysregulation of the body’s response to infection rather than a progressive systemic inflammation. Since sepsis is based on a pathobiological process, its definitions should be applied both to adults and children. However, the terminology and intensive care of pediatric sepsis is beyond the recommendations of Sepsis-3. Over the last 3 years the scientists have studied various pediatric scales to verify sepsis and introduce the Sepsis-3 ideology into pediatrics. Currently, the consensus and multidisciplinary approach of pediatricians and intensive care physicians is extremely important to achieve real success in early diagnosis and reduce mortality in children with sepsis.