Open AccessAnti-NMDAR autoimmune encephalitis in children and herpes simplex virus-1
Author(s) -
Е. Ю. Скрипченко,
Г Ф Железникова,
Н В Скрипченко,
Л. А. Алексеева,
А. В. Суровцева
Publication year - 2019
Publication title -
rossijskij vestnik perinatologii i pediatrii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.139
H-Index - 4
eISSN - 2500-2228
pISSN - 1027-4065
DOI - 10.21508/1027-4065-2019-64-3-17-27
Subject(s) - encephalitis , autoimmune encephalitis , immunology , herpes simplex virus , medicine , disease , pathogenesis , virology , immunotherapy , virus , immune system , pathology
The review focuses on autoimmune encephalitis with antibodies to NMDA receptors, previously unknown autoimmune disease of the central nervous system, described in 2007. Anti-NMDAR encephalitis develops in adults and children, due to the tumor process and without it, it is manifested by characteristic syndrome of neurological and mental disorders. The authors separate anti-NMDAR encephalitis, which develops after the resolution of encephalitis caused by the herpes simplex virus-1. They describe the clinical manifestations of anti-NMDAR encephalitis in children and the effectiveness of early immunotherapy. Perspectively they discuss the pathogenesis of the disease, as well as the connection of herpes simplex virus infection and the development of anti-NMDAR encephalitis.