Open AccessEarly congenital syphilis: solved and unresolved problems of diagnosis
Author(s) -
Н. В. Матыскина,
T.E. Taranushenko
Publication year - 2019
Publication title -
rossijskij vestnik perinatologii i pediatrii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.139
H-Index - 4
eISSN - 2500-2228
pISSN - 1027-4065
DOI - 10.21508/1027-4065-2019-64-2-75-80
Subject(s) - syphilis , congenital syphilis , treponema , titer , immunoassay , medicine , polymerase chain reaction , clinical diagnosis , hemagglutination , immunology , virology , pediatrics , antibody , biology , genetics , human immunodeficiency virus (hiv) , gene
Objective. To analyze the results of clinical and laboratory studies of children born to women with syphilitic infection, and select the most clinically significant criteria to optimize the diagnosis of early congenital syphilis. Methods. A comprehensive clinical and laboratory examination of 547 newborns born to women with a syphilitic infection. Results. The diagnostic sensitivity of the enzyme immunoassay with the determination of specific IgM was 86.6%, the polymerase chain reaction with the detection of Treponema pallidum DNA was 91.6%. Conclusion. The examination of newborns from mothers with a syphilitic infection can be optimized by reducing the number of laboratory techniques (microprecipitation reaction and passive haemagglutination reaction), subject to the mandatory determination of specific IgM and IgG in the first day of life, followed by further confirmation of diagnostics (IgG titer dynamics and the determination of the presence of T. pallidum DNA, as well as instrumental methods of research).