Open AccessPARTICIPATION OF VITAMIN D IN PATHOGENESIS OF CARDIOVASCULAR DISEASES
Author(s) -
Колесников Андрей Николаевич,
Дубовая Анна Валериевна,
Удовитченко Юлия Владимировна
Publication year - 2018
Publication title -
rossijskij vestnik perinatologii i pediatrii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.139
H-Index - 4
eISSN - 2500-2228
pISSN - 1027-4065
DOI - 10.21508/1027-4065-2018-63-5-43-50
Subject(s) - medicine , blood pressure , cardiology , disease , vitamin d and neurology , pathogenesis , sudden cardiac death , randomized controlled trial , coronary heart disease , cholesterol
The article presents data of experimental and clinical studies devoted to the influence of vitamin D on the origin and progression of the cardiovascular diseases: arterial hypertension, atherosclerosis, coronary heart disease, cardiac rhythm disturbances. The results of the studies indicate that a pronounced deficiency of vitamin D is highly correlated with sudden cardiac death, cardiovascular catastrophes, and overall mortality. The decrease in vitamin D is followed by an increase in total cholesterol, low-density lipoproteins and triglycerides, an increase in the heart rate and the level of systolic blood pressure. The Meta-analyzes of randomized controlled trials demonstrated that the addition of vitamin D to treatment and rehabilitation measures of the patients with cardiovascular disease helps to reduce overall mortality.