Open AccessFormulation of Isoniazide Sustained Release Formulation by Using Carbopol 934 P
Author(s) -
Addanki Gopikrishna,
Ramu Bandameedi,
G. Srikanth,
B. Rajkamal
Publication year - 2016
Publication title -
international journal of applied pharmaceutical sciences and research
Language(s) - English
Resource type - Journals
ISSN - 2455-8095
DOI - 10.21477/ijapsr.v1i2.10177
Subject(s) - guar gum , chemistry , polymer , controlled release , dissolution , pharmacology , chromatography , materials science , medicine , organic chemistry , food science
The aim of the present study was to develop sustained release formulation of Isoniazide to maintain constant therapeutic levels of the drug for over 12 hrs. Various polymers such as Guar gum, HPMCK100 M, PEG 6000 and Carbopol 934 p were employed as polymers. Isoniazide dose was fixed as 100 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the concentration of 100, 150 and 200 mg. All the formulations passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,96.10 % in 12 hours. It followed zero order release kinetics.