Open AccessNeuroprotective Effect of Nevirapine on Cerebral Ischemic Stroke by Middle Cerebral Artery Occlusion in Wistar Rats
Author(s) -
CH Maneesha Ram,
Nazia Begum,
P Naveen,
Vasudha Bakshi
Publication year - 2016
Publication title -
international journal of applied pharmaceutical sciences and research
Language(s) - English
Resource type - Journals
ISSN - 2455-8095
DOI - 10.21477/ijapsr.v1i1.9604
Subject(s) - neuroprotection , glutathione peroxidase , pharmacology , neurotoxicity , medicine , superoxide dismutase , middle cerebral artery , stroke (engine) , anesthesia , lactate dehydrogenase , antioxidant , ischemia , oxidative stress , chemistry , endocrinology , biochemistry , toxicity , enzyme , mechanical engineering , engineering
Objective: To evaluate the neuroprotective effect of Nevirapine on cerebral ischemia stroke by middle cerebral artery occlusion in wistar rats. Methods: The rats were pre and post treated with Nevirapine (NVP) at selective doses (5, 10 mg/kg/g, p.o) for a period of 14 days followed by middle cerebral artery occlusion (MCAO). Neurobehavioral changes were evaluated by using Y-maze and open field habituation. Biochemical markers such as acetyl cholinesterase (AChE), glutamate, differential leukocyte count (DLC), lactate dehydrogenase (LDH), antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase were estimated. Results: Obtain results revealed that 14 days of treatment with NVP was effective in averting neurotoxicity. NVP treatment significantly reduced AChE, glutamate, DLC, LDH and elevated levels of antioxidant parameters such as SOD, catalase and GPX.. Conclusion: These results clearly revealed that Nevirapine exhibited cognitive improvement which is related to its antioxidant and neuroprotective activity. Further studies are suggested to evaluate molecular mechanism of involved in neuroprotection.