Open AccessDesign and Development of Transdermal Patches of Antipsychotic Drug: In vitro and Ex vivo Characterization
Author(s) -
Himabindu Peddapalli,
Anjaneyulu Rajagoni,
Preethi Pagilla,
Jerusha Perumala,
Shilpa Puppala,
Katta Sunand,
Vasudha Bakshi
Publication year - 2020
Publication title -
international journal of applied pharmaceutical sciences and research
Language(s) - English
Resource type - Journals
ISSN - 2455-8095
DOI - 10.21477/ijapsr.5.3.2
Subject(s) - transdermal , folding endurance , plasticizer , chromatography , permeation , isopropyl myristate , dialysis tubing , materials science , chemistry , bioavailability , drug , pharmaceutics , solubility , pharmacology , membrane , first pass effect , medicine , composite material , organic chemistry , biochemistry
The purpose of the present research work was to design, assess, and estimate the developed transdermal matrix-typeformulation comprising levosulpiride hydrochloride with the objective of enhancing the bioavailability and compliance ofthe patient. Transdermal films of levosulpiride were developed using a solvent casting method by hydroxypropyl methylcellulose(HPMC) E 15, Eudragit RL 100, and Eudragit RS100. In current research work, propylene glycol and oleic acidwas used as plasticizer and permeation enhancers in different fractions. Among the batches, drug content uniformity withall formulations was perceived between 91.6 to 98%. Folding endurance of patches was good and indicates satisfactoryflexibility. Developed transdermal films had the necessary physicochemical properties, for example, uniformity of drugcontent, weight, thickness, folding endurance, and dampness content. Franz diffusion cell was used for in vitro diffusionstudies utilizing dialysis membrane as a pervasion boundary. Formulation F5 (Eudragit RL 100-1%, HPMC E15-9%) wasfound to be best among all batches of its consistent release rate for 12 hours and the extent of drug release 97.76%. F5was the most palatable formulation as it firmly meets the standards and continuously permeated drugs for 12 hours thatcan keep up desired therapeutic concentration in plasma. The patches were exposed to transient stability studies and wereobserved to be constant and stable.