Open AccessFormulation, Development, and Optimization of Anti- Hypertensive Nisoldipine Extended-Release Tablet Formulation
Author(s) -
Kukkadapu Pavan Kumar,
Katta Sunand,
Nerella Mounika,
Mohammed Abdul Samad,
A. Madhu Babu,
Krishna Mohan Chinnala
Publication year - 2020
Publication title -
international journal of applied pharmaceutical sciences and research
Language(s) - English
Resource type - Journals
ISSN - 2455-8095
DOI - 10.21477/ijapsr.5.3.1
Subject(s) - nisoldipine , friability , dosage form , controlled release , pharmacology , drug delivery , drug , active ingredient , materials science , solubility , chromatography , chemistry , biomedical engineering , medicine , calcium , nifedipine , nanotechnology , first pass effect , organic chemistry
A drug molecule has to be water-soluble to be readily delivered to the cellular membrane. Many drugs are waterinsoluble,which creates numerous problems in the development of dosage forms. Controlled drug deliveryformulation releases the drug with controlled kinetics for days and months, reducing the frequency of dosing,minimizing side effects, and improving patient compliance. Nisoldipine is a calcium channel antagonist that isindicated for the treatment of hypertension with very poor aqueous solubility. Thus, there is a need to improvethe rate of drug release. Hence, the study was carried out to design, formulate and evaluate sustained-releasetablet formulation of nisoldipine. Nisoldipine controlled release matrix tablets were prepared by roll compactionmethod. Preformulation studies have confirmed the purity and compatibility of drug with excipients used in theformulation. Pre-compression studies have confirmed the stability of formulation blends for compression. Allthe prepared formulations were evaluated for various physical and compression parameters such as bulk andtapped density, hardness, friability, and in vitro drug release studies. The results of drug release from preparedcompressed nisoldipine extended-release tablets were found to be within the desired range.