Open AccessMedicinal Applications of Antisense Oligonucleotides: A Review
Author(s) -
Kavya Pandiri,
Mohammed Abdul Samad,
Nadeem Abbas Gulamus,
Hajera Khanam
Publication year - 2020
Publication title -
international journal of applied pharmaceutical sciences and research
Language(s) - English
Resource type - Journals
ISSN - 2455-8095
DOI - 10.21477/ijapsr.5.2.2
Subject(s) - oligonucleotide , antisense therapy , computational biology , rna , biology , antisense rna , dna , gene , microbiology and biotechnology , genetics , locked nucleic acid
Antisense technology has emerged as a fast and conceivably high-throughput method for repressing genes dueto advancement in knowledge about DNA and RNA physiology. The limitations of antisense oligonucleotidetherapy in delivery strategies have been overcome in recent years. Antisense oligonucleotide treatment waseffectively applied towards targeting a wide range of therapeutic areas. With ongoing approvals of antisenseoligonucleotides, there is an expanding enthusiasm for increasing the utilization of these compounds for curingvarious infections. This short survey gives a far-reaching comprehension of applications of antisense technology,how they can be utilized therapeutically, and current endeavors to grow new antisense oligonucleotidetreatments that will add a forthcoming therapeutic approach for the treatment of various diseases.