Open AccessPEMPHIGOID GESTATIONIS : CASE REPORT AND REVIEW OF LITTERATURE
Author(s) -
Badsi Safae,
Louzali Fatima Zahra,
Benaouicha Nisrine,
Najia Zeraidi,
Amina Lakhdar,
Kherbache Aicha,
Aziz Baidada
Publication year - 2022
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/14491
Subject(s) - medicine , pregnancy , dermatology , bullous pemphigoid , pathophysiology , histopathological examination , corticosteroid , autoantibody , pemphigoid , fetus , pathology , surgery , immunology , antibody , biology , genetics
Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis associated with pregnancy. Its previous designation, herpes gestationis, is obsolete. PG is characterized by a subepidermic separation induced by the presence of peripheral blood autoantibodies against two hemidesmosomal antigens: BPAG1 and BPAG2. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence tests. The most discriminant examination for other pruritic dermatoses of pregnancy is the enzyme-linked immunosorbent assay (Elisa) NC16A BP 180. First-line treatment is local corticosteroid therapy if local treatment fails, general corticosteroid therapy should be administered. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Management in a specialized setting is therefore necessary. Recurrence is possible during subsequent pregnancies. We report a case of PG identified in our department, with a review of literature about physiopathology, diagnosis and treatment of this rare pathology.