Open AccessLE PHEOCHROMOCYTOME-GANGLIONEUROME COMPOSITE AVEC SECRETION ECTOPIQUE DACTH : UNE TUMEUR EXCEPTIONNELLE DE LA SURRENALE
Author(s) -
Cornelly Ahouissoussi,
Charlene-Ludwine Bifoume Ndong,
Sana Rafi,
Ghizlane El Mghari Tabib,
N. El Ansari,
Hanane Rais
Publication year - 2022
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/14126
Subject(s) - ganglioneuroma , pheochromocytoma , medicine , adrenalectomy , pathology , surgery , neuroblastoma , biology , genetics , cell culture
Introduction: Pheochromocytoma is an exceptional cause of Cushings syndrome. We report the very exceptional case of a composite pheochromocytoma-ganglioneuroma with ectopic secretion of adrenocorticotrophic hormone, two rare histological entities grouped into one, in a patient with a complex clinical feature. Case Report: This is a 62-year-old patient consulting for polyarthralgia and low back pain in whom the physical examination found Cushings syndrome. The thoraco-abdomino-pelvic computed tomography showed bilateral adrenal masses. A left adrenalectomy was performed first. Histological examination shows a double contingent tumor proliferation. The diagnosis of composite pheochromocytoma-ganglioneuroma with ectopic adrenocorticotrophic hormone secretion was retained. Discussion and Conclusion: We have not found any reported case of ectopic secretion of adrenocorticotrophic hormone linked to a composite pheochromocytoma-ganglioneuroma in the French and English literature during the last 10 years. The diagnosis is essentially histological because clinical and radiological data do not allow it to be differentiated from a classic pheochromocytoma. This entity highlights diagnostic and therapeutic difficulties.