Open AccessALCOHOL INDUCED OXIDATIVE STRESS IN TESTES OF EXPERIMENTAL ANIMALS
Author(s) -
Gireesh Kumar K.M,
AUTHOR_ID,
Sumesh V.K,
V. Devi Rajeswari,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2022
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/14002
Subject(s) - oxidative stress , alcohol , glutathione , ethanol , chemistry , glutathione reductase , superoxide dismutase , biochemistry , medicine , endocrinology , biology , enzyme , glutathione peroxidase
A study was conducted to evaluate the alcohol induced oxidative Stress (OS) in the testes of experimental animals. Albino rats of Wister stain weighing 200-220 g were used for the study. The experimental groups received 1.6 g of ethanol/kg of body weight/day for 12 weeks. It was observed that alcohol used for a long period caused significant OS in the testes as a result of the generation of Super Oxide (SO) radical due to the alcohol metabolism. A significant reduction in glutathione and increased in barbituric acid reactive substances were observed. SO dismutase activity and glutathione reductase activity decreased significantly in the experimental group.