ALCOHOL INDUCED OXIDATIVE STRESS IN TESTES OF EXPERIMENTAL ANIMALS | Zendy

Gireesh Kumar K.M | Zendy; Sumesh V.K | Zendy; V. Devi Rajeswari | Zendy

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ALCOHOL INDUCED OXIDATIVE STRESS IN TESTES OF EXPERIMENTAL ANIMALS

Author(s) -

Gireesh Kumar K.M,

Sumesh V.K,

V. Devi Rajeswari

Publication year - 2022

Publication title -

international journal of advanced research

Language(s) - English

Resource type - Journals

ISSN - 2320-5407

DOI - 10.21474/ijar01/14002

Subject(s) - oxidative stress , alcohol , glutathione , ethanol , glutathione reductase , chemistry , superoxide dismutase , biochemistry , medicine , endocrinology , biology , enzyme , glutathione peroxidase

A study was conducted to evaluate the alcohol induced oxidative Stress (OS) in the testes of experimental animals. Albino rats of Wister stain weighing 200-220 g were used for the study. The experimental groups received 1.6 g of ethanol/kg of body weight/day for 12 weeks. It was observed that alcohol used for a long period caused significant OS in the testes as a result of the generation of Super Oxide (SO) radical due to the alcohol metabolism. A significant reduction in glutathione and increased in barbituric acid reactive substances were observed. SO dismutase activity and glutathione reductase activity decreased significantly in the experimental group.

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